Peptide T

• CAT Number: I013415
• CAS Number: 106362-32-7
• Molecular Formula: C₃₅H₅₅N₉O₁₆
• Molecular Weight: 857.86
• Purity: ≥95%
• Target: HIV
• Solubility: DMSO
• IUPAC Name: (2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoic acid
• InChI: InChI=1S/C35H55N9O16/c1-13(36)28(52)40-22(12-45)31(55)41-25(15(3)47)33(57)43-26(16(4)48)34(58)42-24(14(2)46)32(56)39-21(11-23(37)51)29(53)38-20(10-18-6-8-19(50)9-7-18)30(54)44-27(17(5)49)35(59)60/h6-9,13-17,20-22,24-27,45-50H,10-12,36H2,1-5H3,(H2,37,51)(H,38,53)(H,39,56)(H,40,52)(H,41,55)(H,42,58)(H,43,57)(H,44,54)(H,59,60)/t13-,14+,15+,16+,17+,20-,21-,22-,24-,25-,26-,27-/m0/s1
• InChIKey: IWHCAJPPWOMXNW-LYKMMFCUSA-N
• SMILES: C[C@H]([C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)O

Peptide T（Cat No.:I013415）is an octapeptide derived from the HIV envelope protein gp120, known for its potential to block the binding of HIV to CD4 receptors on immune cells. By interfering with this interaction, Peptide T may inhibit viral replication and cell entry. Beyond its antiviral activity, Peptide T has been investigated for its neuroprotective effects, particularly in addressing HIV-associated neurocognitive disorders (HAND). Its ability to modulate inflammation and neurodegeneration highlights its therapeutic potential in HIV research and other neurological conditions involving immune activation and cellular damage.

Reference

[1]. Ferreira LA, et al. Peptide T, a novel bradykinin potentiator isolated from Tityus serrulatus scorpion venom. Toxicon. 1993 Aug;31(8):941-7.[2]. Heseltine PN, et al. Randomized double-blind placebo-controlled trial of peptide T for HIV-associated cognitive impairment. Arch Neurol. 1998 Jan;55(1):41-51.[3]. Pert CB, et al. Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9254-8.