Peramivir

• CAT Number: I003184
• CAS Number: 330600-85-6
• Molecular Formula: C15H28N4O4
• Molecular Weight: 328.41
• Purity: ≥95%
• Synonyms: (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.09 nM
• InChI: InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1
• InChIKey: XRQDFNLINLXZLB-CKIKVBCHSA-N
• SMILES: CCC(CC)[C@@H]([C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)O)N=C(N)N)NC(=O)C

Peramivir（Cat No.:I003184）is an antiviral medication and neuraminidase inhibitor used to treat acute influenza infections, particularly in severe cases or when other treatments are ineffective. Administered via intravenous infusion, it works by blocking the neuraminidase enzyme on the influenza virus, preventing viral replication and spread within the respiratory tract. Approved for use in cases where rapid treatment is necessary, peramivir offers the advantage of a single-dose regimen, making it convenient for hospitalized patients. Its effectiveness against influenza A and B strains adds versatility, making it a valuable tool in influenza management.

Reference

[1]. Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infection By Sugaya, Norio; Kohno, Shigeru; Ishibashi, Toru; Wajima, Toshihiro; Takahashi, Takao From Antimicrobial Agents and Chemotherapy.
[2]. Louie JK, Yang S, Yen C, Acosta M, Schechter R, Uyeki TM. Use of Intravenous Peramivir for Treatment of Severe Influenza A(H1N1)pdm09. PLoS One. 2012;7(6):e40261.
[3]. Sakata H. Clinical efficiency in children treated with intravenous drip infusion of peramivir.Jpn J Antibiot. 2011 Dec;64(6):383-7.
[4]. Abed Y, Pizzorno A, Boivin G. Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation. Antimicrob Agents Chemother. 2012 Aug;56(8):4375-80.
[5]. Hikita T, Hikita H, Hikita F, Hikita N, Hikita S. Clinical effectiveness of peramivir in comparison with other neuraminidase inhibitors in pediatric influenza patients.Int J Pediatr. 2012;2012:834181.