Peresolimab

• CAT Number: I040851
• CAS Number: 2411580-63-5
• Purity: ≥95%

Peresolimab (Cat No.: I040851) is a humanized IgG1 monoclonal antibody that targets PD-1 (programmed cell death protein 1), acting as an agonist rather than a blocker. Unlike traditional PD-1 inhibitors used in cancer therapy, Peresolimab activates PD-1 signaling to suppress overactive immune responses, making it a promising candidate for treating autoimmune diseases such as rheumatoid arthritis. It modulates T cell activity to restore immune balance. Peresolimab is a novel immunomodulatory tool for exploring PD-1 agonism. For research use only.

Reference

[1]. Tuttle J, et al. Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis. Reply. N Engl J Med. 2023 Jul 27;389(4):378-379.
[Content Brief]

[2]. Peresolimab. IMGT/mAb-DB.