For research use only. Not for therapeutic Use.
Perifosine (KRX-0401)（Cat No.:I002001）is an oral alkylphosphocholine compound with anticancer properties. It acts as an Akt pathway inhibitor, preventing Akt activation and disrupting cell survival and proliferation signaling. Perifosine also targets other pathways, including MAPK and JNK, contributing to its antitumor effects. It induces apoptosis and inhibits angiogenesis, making it effective against various cancers, including multiple myeloma, colorectal, and breast cancers. With its unique mechanism and ability to overcome resistance to other therapies, Perifosine is a promising agent for cancer treatment and ongoing clinical research.
| Catalog Number | I002001 |
| CAS Number | 157716-52-4 |
| Synonyms | (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate |
| Molecular Formula | C₂₅H₅₃NO₄P |
| Purity | ≥95% |
| Target | Akt |
| Solubility | H2O: 125 mg/mL, DMSO: ＜ 1.2 mg/mL |
| Storage | 3 years -20C powder |
| IUPAC Name | (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate |
| InChI | InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3 |
| InChIKey | SZFPYBIJACMNJV-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C |
| Reference | </br>1:Phase I study of perifosine monotherapy in patients with recurrent or refractory neuroblastoma. Matsumoto K, Shichino H, Kawamoto H, Kosaka Y, Chin M, Kato K, Mugishima H.Pediatr Blood Cancer. 2017 May 18. doi: 10.1002/pbc.26623. [Epub ahead of print] PMID: 28521076 </br>2:Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine. Egler J, Lang F.Cell Physiol Biochem. 2017 May 4;41(6):2534-2544. doi: 10.1159/000475977. [Epub ahead of print] PMID: 28472790 Free Article</br>3:Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma. Gu X, Hua Z, Dong Y, Zhan Y, Zhang X, Tian W, Liu Z, Thiele CJ, Li Z.Sci Rep. 2017 Feb 6;7:42062. doi: 10.1038/srep42062. PMID: 28165023 Free PMC Article</br>4:Perifosine Mechanisms of Action in Leishmania Species. López-Arencibia A, Martín-Navarro C, Sifaoui I, Reyes-Batlle M, Wagner C, Lorenzo-Morales J, Maciver SK, Piñero JE.Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02127-16. doi: 10.1128/AAC.02127-16. Print 2017 Apr. PMID: 28096161 </br>5:A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors. Becher OJ, Gilheeney SW, Khakoo Y, Lyden DC, Haque S, De Braganca KC, Kolesar JM, Huse JT, Modak S, Wexler LH, Kramer K, Spasojevic I, Dunkel IJ.Pediatr Blood Cancer. 2016 Dec 30. doi: 10.1002/pbc.26409. [Epub ahead of print] PMID: 28035748 </br>6:A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma. Kushner BH, Cheung NV, Modak S, Becher OJ, Basu EM, Roberts SS, Kramer K, Dunkel IJ.Int J Cancer. 2017 Jan 15;140(2):480-484. doi: 10.1002/ijc.30440. Epub 2016 Sep 30. PMID: 27649927 </br>7:Perifosine and ABT-737 synergistically inhibit lung cancer cells in vitro and in vivo. Shen J, Xu L, Zhao Q.Biochem Biophys Res Commun. 2016 May 13;473(4):1170-6. doi: 10.1016/j.bbrc.2016.04.035. Epub 2016 Apr 9. PMID: 27073162 </br>8:Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine. Delgado-Ramírez M, Morán-Zendejas R, Aréchiga-Figueroa IA, Toro-Castillo C, Ramírez-Martínez JF, Rodríguez-Menchaca AA.Pharmacol Rep. 2016 Apr;68(2):457-61. doi: 10.1016/j.pharep.2015.11.006. Epub 2015 Nov 28. PMID: 26922553 </br>9:Low-concentration of perifosine surprisingly protects cardiomyocytes from oxygen glucose deprivation. Zheng K, Lu H, Sheng Z, Li Y, Xu B.Biochem Biophys Res Commun. 2016 Jan 15;469(3):753-60. doi: 10.1016/j.bbrc.2015.12.014. Epub 2015 Dec 11. PMID: 26686418 </br>10:Perifosine as a potential novel anti-telomerase therapy. Holohan B, Hagiopian MM, Lai TP, Huang E, Friedman DR, Wright WE, Shay JW.Oncotarget. 2015 Sep 8;6(26):21816-26. PMID: 26307677 Free PMC Article |
