PERK-IN-44（Cat No.:I034454）is a selective inhibitor of the protein kinase PERK (PKR-like ER kinase), which plays a critical role in the unfolded protein response (UPR) and cellular stress responses. By inhibiting PERK, this compound can disrupt the survival pathways activated under stress conditions, particularly in cancer cells that rely on UPR for survival. Research indicates that PERK-IN-44 may enhance the effectiveness of other cancer therapies, making it a promising candidate for combination treatments. Its potential applications in oncology are being explored, particularly for tumors with high levels of ER stress or UPR activation.
| Catalog Number | I034454 |
| CAS Number | 1883548-84-2 |
| Synonyms | PERK-IN-44 |
| Molecular Formula | C34H29ClN4O2 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| IUPAC Name | 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one;hydrochloride |
| InChI | InChI=1S/C34H28N4O2.ClH/c1-21-14-18-27(31(35)29(21)25-17-19-28-24(20-25)16-15-22(2)36-28)33(39)30-32(23-10-6-4-7-11-23)37(3)38(34(30)40)26-12-8-5-9-13-26;/h4-20H,35H2,1-3H3;1H |
| InChIKey | RNAKBTDDCHJCMT-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=C(C=C1)C(=O)C2=C(N(N(C2=O)C3=CC=CC=C3)C)C4=CC=CC=C4)N)C5=CC6=C(C=C5)N=C(C=C6)C.Cl |
