For research use only. Not for therapeutic Use.
PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1].
PERK-IN-6 (Compound 5) inhibits thapsigargin induced PERK autophosphorylation with an IC50 of 0.1-0.3 μΜ in A549 cells[1].
The rat blood clearance of PERK-IN-6 (Compound 5) is 10.5 mL/min/kg after i.v infusion in SD rats[1].
| Catalog Number | I041304 |
| CAS Number | 1337532-14-5 |
| Synonyms | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone |
| Molecular Formula | C23H22N6O |
| Purity | ≥95% |
| InChI | InChI=1S/C23H22N6O/c1-14-4-3-5-17(27-14)11-20(30)29-9-8-16-10-15(6-7-19(16)29)18-12-28(2)23-21(18)22(24)25-13-26-23/h3-7,10,12-13H,8-9,11H2,1-2H3,(H2,24,25,26) |
| InChIKey | VYZYOJULVVGQRS-UHFFFAOYSA-N |
| SMILES | CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3)C4=CN(C5=NC=NC(=C45)N)C |
| Reference | [1]. Axten JM, et al. Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. ACS Med Chem Lett. 2013 Aug 12;4(10):964-8. |
