PF‑06446846

• CAT Number: I008687
• CAS Number: 1632250-49-7 (free base)
• Molecular Formula: C23H21F6NO3
• Molecular Weight: 473.42
• Purity: ≥95%
• Synonyms: PF‑06446846; PF 06446846; PF06446846;;(R)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide
• Target: Ser/Thr Protease
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide
• InChI: InChI=1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1
• InChIKey: FDTXHWQFIXYHCL-QGZVFWFLSA-N
• SMILES: C1C[C@H](CNC1)N(C2=C(C=CC=N2)Cl)C(=O)C3=CC=C(C=C3)N4C5=C(C=CC=N5)N=N4

PF-06446846（Cat No.:I008687）is an investigational small molecule that acts as a selective antagonist of the vasopressin V1a receptor. Vasopressin is a hormone involved in regulating blood pressure, water balance, and stress response. By targeting the V1a receptor, PF-06446846 has shown potential in treating conditions related to vasopressin dysregulation, such as heart failure, hypertension, and certain forms of anxiety or stress disorders. Research on PF-06446846 is ongoing, focusing on its efficacy and safety profile in clinical settings, particularly in managing cardiovascular diseases and other conditions with overactive vasopressin signaling.