For research use only. Not for therapeutic Use.
PF-00489791 (Cat No.:I008645 ) is an investigational small-molecule inhibitor targeting the Janus kinase (JAK) family of enzymes, specifically JAK1 and JAK3. By blocking these kinases, it modulates the signaling pathways involved in immune response and inflammation. PF-00489791 shows potential for treating autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease (IBD). It has been evaluated in preclinical and early clinical studies, with the goal of improving patient outcomes by targeting specific immune dysregulation without broad immune suppression.
| CAS Number | 853003-48-2 |
| Synonyms | 1-(2-ethoxyethyl)-5-[ethyl(methyl)amino]-7-[(4-methylpyridin-2-yl)amino]-N-methylsulfonylpyrazolo[4,3-d]pyrimidine-3-carboxamide |
| Molecular Formula | C20H28N8O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H28N8O4S/c1-6-27(4)20-23-15-16(19(29)26-33(5,30)31)25-28(10-11-32-7-2)17(15)18(24-20)22-14-12-13(3)8-9-21-14/h8-9,12H,6-7,10-11H2,1-5H3,(H,26,29)(H,21,22,23,24) |
| InChIKey | ZUHZNKJIJDAJFD-UHFFFAOYSA-N |
| SMILES | CCN(C)C1=NC2=C(C(=N1)NC3=NC=CC(=C3)C)N(N=C2C(=O)NS(=O)(=O)C)CCOCC |
| Reference | [1]. Frank S Menniti, et al. A non-brain penetrant PDE5A inhibitor improves functional recovery after stroke in rats. Restor Neurol Neurosci. 2012;30(4):283-9. |
