PF-03463275

• CAT Number: I008654
• CAS Number: 1173177-11-1
• Molecular Formula: C19H22ClFN4O
• Molecular Weight: 376.86
• Purity: ≥95%
• Synonyms: PF-03463275; PF03463275; PF 03463275; KB-79869; KB 79869.;N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide
• Target: CNS-Penetrant Inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide
• InChI: InChI=1S/C19H22ClFN4O/c1-23-7-13-14(8-23)15(13)9-25(19(26)18-10-24(2)11-22-18)6-12-3-4-17(21)16(20)5-12/h3-5,10-11,13-15H,6-9H2,1-2H3/t13-,14+,15?
• InChIKey: KYLOBHXXQOZRKK-YIONKMFJSA-N
• SMILES: CN1C[C@@H]2[C@H](C1)C2CN(CC3=CC(=C(C=C3)F)Cl)C(=O)C4=CN(C=N4)C

PF-03463275(CAT: I008654) is an orally bioavailable, CNS-penetrant inhibitor of SLC6A9, also known as the GlyT1 glycine transporter. By inhibiting GlyT1, it modulates glycine levels at the NMDA receptor, enhancing glutamatergic neurotransmission. This mechanism has been investigated for its potential in treating schizophrenia, particularly in addressing cognitive and negative symptoms associated with the disorder. PF-03463275 is a valuable compound in neuroscience research, offering insights into glycine transporter inhibition as a therapeutic strategy for neuropsychiatric conditions.