For research use only. Not for therapeutic Use.
PF-03715455 is a selective p38 alpha mitogen-activated protein kinase (MAPK 14) inhibitor, with a crystalline form suitable for powder inhalation and low drug interaction potential. PF 3715455 is used for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
| Catalog Number | I008658 |
| CAS Number | 1056164-52-3 |
| Synonyms | PF-03715455; PF 03715455; PF03715455; PF-3715455; PF 3715455; PF3715455.;1-(3-(tert-butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio)benzyl)urea |
| Molecular Formula | C35H34ClN7O3S2 |
| Purity | 98% |
| Documentation | |
| Target | p38 MAPK 14 Inhibitor |
| Appearance | Solid powder |
| IUPAC Name | 1-[5-tert-butyl-2-(3-chloro-4-hydroxyphenyl)pyrazol-3-yl]-3-[[2-[[3-[2-(2-hydroxyethylsulfanyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl]phenyl]methyl]urea |
| InChI | InChI=1S/C35H34ClN7O3S2/c1-35(2,3)30-19-32(43(41-30)23-12-14-27(45)26(36)18-23)38-34(46)37-20-22-8-4-6-10-28(22)48-24-13-15-31-39-40-33(42(31)21-24)25-9-5-7-11-29(25)47-17-16-44/h4-15,18-19,21,44-45H,16-17,20H2,1-3H3,(H2,37,38,46) |
| InChIKey | VGEXRDWWPSGZDH-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=NN(C(=C1)NC(=O)NCC2=CC=CC=C2SC3=CN4C(=NN=C4C5=CC=CC=C5SCCO)C=C3)C6=CC(=C(C=C6)O)Cl |
