PF-03715455

• CAT Number: I008658
• CAS Number: 1056164-52-3
• Molecular Formula: C35H34ClN7O3S2
• Molecular Weight: 700.273
• Purity: 98%
• Synonyms: PF-03715455; PF 03715455; PF03715455; PF-3715455; PF 3715455; PF3715455.;1-(3-(tert-butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio)benzyl)urea
• Target: p38 MAPK 14 Inhibitor
• Appearance: Solid powder
• IUPAC Name: 1-[5-tert-butyl-2-(3-chloro-4-hydroxyphenyl)pyrazol-3-yl]-3-[[2-[[3-[2-(2-hydroxyethylsulfanyl)phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl]phenyl]methyl]urea
• InChI: InChI=1S/C35H34ClN7O3S2/c1-35(2,3)30-19-32(43(41-30)23-12-14-27(45)26(36)18-23)38-34(46)37-20-22-8-4-6-10-28(22)48-24-13-15-31-39-40-33(42(31)21-24)25-9-5-7-11-29(25)47-17-16-44/h4-15,18-19,21,44-45H,16-17,20H2,1-3H3,(H2,37,38,46)
• InChIKey: VGEXRDWWPSGZDH-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=NN(C(=C1)NC(=O)NCC2=CC=CC=C2SC3=CN4C(=NN=C4C5=CC=CC=C5SCCO)C=C3)C6=CC(=C(C=C6)O)Cl

PF-03715455 is a selective p38 alpha mitogen-activated protein kinase (MAPK 14) inhibitor, with a crystalline form suitable for powder inhalation and low drug interaction potential. PF 3715455 is used for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.