PF-04418948

• CAT Number: I000351
• CAS Number: 1078166-57-0
• Molecular Formula: C₂₃H₂₀FNO₅
• Molecular Weight: 409.41
• Purity: ≥95%
• Synonyms: 1-(4-fluorobenzoyl)-3-(((6-methoxynaphthalen-2-yl)oxy)methyl)azetidine-3-carboxylic acid
• Target: Prostaglandin Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 16 nM
• IUPAC Name: 1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid
• InChI: InChI=1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
• InChIKey: LWJGMYMNSNVCEM-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O

PF-04418948（Cat No.:I000351）is a small molecule inhibitor that targets the enzyme phosphodiesterase 9A (PDE9A), which regulates cyclic GMP (cGMP) levels within cells. By inhibiting PDE9A, PF-04418948 helps to increase cGMP levels, which has potential therapeutic effects on conditions related to neurodegeneration, such as Alzheimer’s disease. cGMP is involved in various cellular processes, including memory and cognitive function, and enhancing its levels may improve neuronal function. Research is ongoing to evaluate the efficacy of PF-04418948 in preclinical and clinical settings for treating neurological disorders and other conditions influenced by PDE9A.