PF-04634817

• CAT Number: I008661
• CAS Number: 1228111-63-4
• Molecular Formula: C25H36F3N5O3
• Molecular Weight: 511.59
• Purity: ≥95%
• Synonyms: PF-04634817; PF 04634817; PF04634817; PF-4634817; PF 4634817; PF4634817.;((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)amino)cyclopentyl)((1S,4S)-5-(6-(trifluoromethyl)pyrimidin-4-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methanone
• Target: Immunology/Inflammation
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: [(1S,3R)-3-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[(1S,4S)-5-[6-(trifluoromethyl)pyrimidin-4-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]methanone
• InChI: InChI=1S/C25H36F3N5O3/c1-15(2)24(6-4-16(10-24)31-19-5-7-36-13-20(19)35-3)23(34)33-12-17-8-18(33)11-32(17)22-9-21(25(26,27)28)29-14-30-22/h9,14-20,31H,4-8,10-13H2,1-3H3/t16-,17+,18+,19+,20-,24+/m1/s1
• InChIKey: MCRWZBYTLVCCJJ-DKALBXGISA-N
• SMILES: CC(C)C1(CCC(C1)NC2CCOCC2OC)C(=O)N3CC4CC3CN4C5=NC=NC(=C5)C(F)(F)F

PF-04634817(CAT: I008661) is an orally administered dual chemokine receptor antagonist targeting CCR2 and CCR5, widely utilized in metabolic and renal disease research. This compound is being investigated for its therapeutic potential in treating diabetic nephropathies and diabetic macular edema. By inhibiting CCR2 and CCR5, PF-04634817 disrupts chemokine signaling pathways associated with inflammation and fibrosis, which are key contributors to the progression of diabetic complications. Its dual-action mechanism provides valuable insights into the role of chemokine receptors in metabolic diseases, making it an essential tool for preclinical studies and drug development focused on improving outcomes in diabetes-related conditions.