PF-04856264

• CAT Number: I008665
• CAS Number: 1235397-05-3
• Molecular Formula: C20H15N5O3S2
• Molecular Weight: 437.49
• Purity: ≥95%
• Synonyms: PF-04856264; PF04856264; PF 04856264; PF-4856264; PF4856264; PF 4856264.;3-cyano-4-(2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-N-(thiazol-2-yl)benzenesulfonamide
• Target: Sodium Channel
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 3-cyano-4-[2-(2-methylpyrazol-3-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzenesulfonamide
• InChI: InChI=1S/C20H15N5O3S2/c1-25-17(8-9-23-25)16-4-2-3-5-19(16)28-18-7-6-15(12-14(18)13-21)30(26,27)24-20-22-10-11-29-20/h2-12H,1H3,(H,22,24)
• InChIKey: MKSKJVIBSRUWSZ-UHFFFAOYSA-N
• SMILES: CN1C(=CC=N1)C2=CC=CC=C2OC3=C(C=C(C=C3)S(=O)(=O)NC4=NC=CS4)C#N

PF-04856264(CAT: I008665) is a potent and selective inhibitor of the human Nav1.7 voltage-gated sodium channel, a critical channel involved in pain signal transmission. By targeting Nav1.7, PF-04856264 disrupts the initiation and propagation of action potentials in nociceptive neurons, making it a promising candidate for pain management. Its high selectivity minimizes off-target effects on other sodium channels, providing a focused approach to modulating pain pathways. PF-04856264 is particularly valuable in neurological and pain research, aiding in the exploration of Nav1.7 as a therapeutic target for conditions such as neuropathic pain and other chronic pain disorders.