PF 05089771

• CAT Number: I011337
• CAS Number: 1430806-04-4
• Molecular Formula: C25H20Cl2FN5O6S3
• Molecular Weight: 672.542
• Purity: ≥95%
• Synonyms: 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate; PF-05089771 tosylate
• Target: Sodium Channel
• Solubility: Soluble to 100 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide;4-methylbenzenesulfonic acid
• InChI: InChI=1S/C18H12Cl2FN5O3S2.C7H8O3S/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17;1-6-2-4-7(5-3-6)11(8,9)10/h1-8,26H,(H3,22,24,25);2-5H,1H3,(H,8,9,10)
• InChIKey: NVKBPDYKPNYMDR-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1=CC(=C(C=C1Cl)C2=C(NN=C2)N)OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=CSC=N4)F

PF-05089771 (CAT: I011337) is a highly pure, synthetic, and biologically active compound. It is characterized by its chemical purity, meaning it is free from impurities or contaminants that could affect its activity or performance. PF-05089771 has been specifically designed and synthesized to exhibit biological activity, typically targeting a specific molecular target or pathway in biological systems. The compound may have been developed for various applications, including research purposes, or as a potential therapeutic agent. Its purity and biological activity make it a valuable tool for scientists and researchers in their investigations and experiments.

Reference

[1]. Sun, S., J Cohen, C. and M Dehnhardt, C., 2014.
Inhibitors of voltage-gated sodium channel Nav1. 7: patent applications since 2010.
Abstarct: There has been intense interest in developing inhibitors of the sodium channel Nav1.7 because genetic studies have established very strong validation for the efficacy to alleviate both inflammatory and neuropathic pain. This review summarizes patent applications targeting Nav1.7 since 2010 until May, 2014. We have classified the patents into three categories as follows: small molecules with well-defined molecular selectivity among sodium channel isoforms; biologicals with well-defined molecular selectivity; and, small molecules that inhibit Nav1.7 with unknown molecular selectivity. Most of the review is dedicated to small molecule selective compounds.
Pharmaceutical patent analyst, 3(5), pp.509-521.

[2]. Tkachenko, P.V., Tkachenko, O.V., Netosova, K.Y., Borisov, O.V., Zhuravel, I.O. and Kazmirchuk, V.V., 2017.
Abstarct: This article is continuation of the development of methods for the synthesis of small molecules based on the structure of 5-aminopyrazole. The synthesis and the antimicrobial activity for a series of new N1-subsituted 5-amino- 4-arylsulfonyl-3-N-phenylaminopyrazoles have been described. Aim. To synthesize derivatives of 5-amino-4-arylsulfonyl-3-phenylaminopyrazoles and study their antimicrobial and antifungal properties. Materials and methods. The methods of organic synthesis, instrumental methods of organic compounds analysis and methods of microbiological screening were used. Results and discussion. 5-Amino-4-arylsulfonyl-3-phenylaminopyrazoles were prepared by the reaction of arylsulfonylacetonitriles with isothiocyanates in the presence of NaOH and CH3I with further cyclization with hydrazine hydrate. The reaction of this compounds with N-arylchloroacetamides finished a series of N1-substituted 5-amino-4-arylsulfonyl- 3-phenylaminopyrazoles. The antibacterial and antifungal properties of the compounds synthesized were studied. Some of the compounds obtained appeared to be potent inhibitors for several pathogenic bacterial and fungal lines. Conclusions. The synthetic scheme for obtaining of N1-substituted 5-amino-4-arylsulfonyl-3-phenylaminopyrazoles, which can be used for creation of a library of compounds for in vitro antimicrobial screening, has been proposed. Some of the compounds synthesized are of certain interest as potential pharmaceutical agents and can be used to develop new antifungal agents
The synthesis and the antimicrobial activity of N1-substituted 5-amino-4-arylsulfonyl-3-N-phenylaminopyrazoles.

[3]. Tkachenko, P.V., Tkachenko, O.V., Netosova, K.Y., Borisov, O.V., Zhuravel, I.O. and Kazmirchuk, V.V., СИНТЕЗ ТА АНАЛІЗ БІОЛОГІЧНО АКТИВНИХ РЕЧОВИН.