For research use only. Not for therapeutic Use.
PF-05105679（Cat No.:I008673）is a selective and potent small molecule inhibitor of the protein kinase CK2 (casein kinase 2). This enzyme plays a critical role in regulating cell growth, survival, and proliferation. PF-05105679 has been studied for its potential therapeutic applications in cancer treatment, as CK2 is often overactive in various cancers. By inhibiting CK2, PF-05105679 may help reduce tumor cell proliferation and enhance the effects of other anticancer therapies. Ongoing research aims to evaluate its efficacy and safety profile in clinical settings for oncology and other diseases.
| Catalog Number | I008673 |
| CAS Number | 1398583-31-7 |
| Synonyms | PF-05105679; PF 05105679; PF05105679; PF-5105679; PF 5105679; PF5105679.;(R)-3-((N-(1-(4-fluorophenyl)ethyl)quinoline-3-carboxamido)methyl)benzoic acid |
| Molecular Formula | C26H21FN2O3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IC50 | 103 nM |
| IUPAC Name | 3-[[[(1R)-1-(4-fluorophenyl)ethyl]-(quinoline-3-carbonyl)amino]methyl]benzoic acid |
| InChI | InChI=1S/C26H21FN2O3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17H,16H2,1H3,(H,31,32)/t17-/m1/s1 |
| InChIKey | BXNMZRPTQFVRFA-QGZVFWFLSA-N |
| SMILES | C[C@H](C1=CC=C(C=C1)F)N(CC2=CC(=CC=C2)C(=O)O)C(=O)C3=CC4=CC=CC=C4N=C3 |
| Reference | </br>1: Andrews MD, Af Forselles K, Beaumont K, Galan SR, Glossop PA, Grenie M, Jessiman A, Kenyon AS, Lunn G, Maw G, Owen RM, Pryde DC, Roberts D, Tran TD. Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain. ACS Med Chem Lett. 2015 Jan 30;6(4):419-24. doi: 10.1021/ml500479v. eCollection 2015 Apr 9. PubMed PMID: 25893043; PubMed Central PMCID: PMC4394344.</br>2:Winchester WJ, Gore K, Glatt S, Petit W, Gardiner JC, Conlon K, Postlethwaite M, Saintot PP, Roberts S, Gosset JR, Matsuura T, Andrews MD, Glossop PA, Palmer MJ, Clear N, Collins S, Beaumont K, Reynolds DS. Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69. doi: 10.1124/jpet.114.216010. Epub 2014 Aug 14. PubMed PMID: 25125580. |
