For research use only. Not for therapeutic Use.
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. ACC inihibitors inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids with potential for treatment of type 2 diabetes, hepatic steatosis, and cancer.
| Catalog Number | I008675 |
| CAS Number | 1301214-47-0 |
| Synonyms | PF-05175157; PF05175157; PF 05175157.;1,4-Dihydro-1/’-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4/’-piperidin]-7(6H)-one |
| Molecular Formula | C23H27N5O2 |
| Purity | ≥95% |
| Target | ACC inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20°C |
| IC50 | 33 nM |
| InChI | InChI=1S/C23H27N5O2/c1-14(2)28-21-17(13-24-28)11-23(12-20(21)29)6-8-27(9-7-23)22(30)16-4-5-18-19(10-16)26-15(3)25-18/h4-5,10,13-14H,6-9,11-12H2,1-3H3,(H,25,26) |
| InChIKey | BDXXSFOJPYSYOC-UHFFFAOYSA-N |
| SMILES | CC(N1[H])=NC2=C1C=C(C(N3CCC4(CC(C=NN5C(C)C)=C5C(C4)=O)CC3)=O)C=C2 |
| Reference | </br>1: Karsch L. Derivation of a formula describing the saturation correction of plane-parallel ionization chambers in pulsed fields with arbitrary repetition rate. Phys Med Biol. 2016 Mar 30;61(8):3222-3236. [Epub ahead of print] PubMed PMID: 27028952.</br>2:Pongcharoen B, Reutiwarangkoon C. The comparison of anterior knee pain in severe and non severe arthritis of the lateral facet of the patella following a mobile bearing unicompartmental knee arthroplasty. Springerplus. 2016 Feb 27;5:202. doi: 10.1186/s40064-016-1914-1. eCollection 2016. PubMed PMID: 27026898. |
