PF-05221304

• CAT Number: I047413
• CAS Number: 1370448-25-1
• Molecular Formula: C28H30N4O5
• Molecular Weight: 502.56
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: COC1=CC(=CC(=N1)C2=CC=C(C=C2)C(O)=O)C(=O)N3CCC4(CC3)CC(=O)C5=C(C4)C=N[N]5C(C)C

PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).

Reference

[1] Arthur Bergman, et al. Clin Pharmacol Drug Dev. 2020 May;9(4):514-526.
[2] Ross TT, et al. Cell Mol Gastroenterol Hepatol. 2020;10(4):829-851.