PF 06260933 dihydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I011985
  • CAS Number: 1883548-86-4
  • Molecular Formula: C16H13ClN4.2HCl
  • Molecular Weight: 369.68
  • Purity: ≥95%
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Potent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis. Robustly prevented TNF-α-mediated endothelial permeability in vitro, similar to MAP4K4 knockdown, and without alteration of plasma lipid content.
Keywords: PF 06260933 dihydrochloride | supplier | MAP4K4 inhibitor | PF06260933 | PF-06260933 | CAS [1883548-86-4] | [1811510-56-1] | MAPK | MAP4K | Inhibitor | HGK | ZC1 | mitogen activated | endothelial | diabetes | vascular inflammation | atherosclerosis | TNF | NF-κB | Enzymes


Catalog Number I011985
CAS Number 1883548-86-4
Molecular Formula C16H13ClN4.2HCl
Purity ≥95%
IUPAC Name 5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine;dihydrochloride
InChI InChI=1S/C16H13ClN4.2ClH/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11;;/h1-9H,(H2,18,20)(H2,19,21);2*1H
SMILES C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl.Cl.Cl
Reference

M. Ammirati et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.

 

R.J. Roth Flach et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015 Dec 21;6:8995.

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