PF-06273340

• CAT Number: I008681
• CAS Number: 1402438-74-7
• Molecular Formula: C23H22ClN7O3
• Molecular Weight: 479.92
• Purity: ≥95%
• Synonyms: N-[5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl]-2-(5-chloropyridin-2-yl)acetamide
• InChI: InChI=1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30)
• InChIKey: BPIWZDNVMQQBQX-UHFFFAOYSA-N
• SMILES: CC(C)(CO)N1C=C(C2=CN=C(N=C21)N)C(=O)C3=CC(=CN=C3)NC(=O)CC4=NC=C(C=C4)Cl

PF-06273340 is a potent, selective, orally bioavailable and peripherally restricted pan Trk inhibitor[1].

Reference

[1]. Skerratt SE, et al. The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
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