PF-06284674

• CAT Number: I034483
• CAS Number: 1434288-24-0
• Molecular Formula: C17H14N4O
• Molecular Weight: 290.326
• Purity: 98%
• Synonyms: PF-06284674
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(1H-Benzimidazol-1-ylmethyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
• InChI: InChI=1S/C17H14N4O/c1-12-5-4-8-16-19-13(9-17(22)21(12)16)10-20-11-18-14-6-2-3-7-15(14)20/h2-9,11H,10H2,1H3
• InChIKey: ICTBPKWPCGSFPZ-UHFFFAOYSA-N
• SMILES: O=C1C=C(CN2C3=CC=CC=C3N=C2)N=C4N1C(C)=CC=C4

PF-06284674 (CAT: I034483) is a potent and selective activator of the M2 isoform of pyruvate kinase (PKM2). PKM2 is a key enzyme involved in glycolysis and plays a critical role in cancer cell metabolism. By activating PKM2, PF-06284674 enhances the conversion of phosphoenolpyruvate (PEP) to pyruvate, promoting the production of ATP and facilitating cancer cell proliferation. PF-06284674’s selectivity for PKM2 makes it a promising therapeutic target for cancer treatment, as it aims to disrupt the metabolic pathways of cancer cells and potentially inhibit tumor growth.