PF-06447475

• CAT Number: I001901
• CAS Number: 1527473-33-1
• Molecular Formula: C₁₇H₁₅N₅O
• Molecular Weight: 305.33
• Purity: ≥95%
• Synonyms: 3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile
• Target: LRRK2
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: room temp
• IC50: 3 nM/11 nM(Wt LRRK2/G2019S LRRK2)
• IUPAC Name: 3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile
• InChI: InChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)
• InChIKey: BHTWDJBVZQBRKP-UHFFFAOYSA-N
• SMILES: C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N

PF-06447475（Cat No.:I001901） is a highly potent, selective, and brain-penetrating inhibitor of the leucine-rich repeat kinase 2 (LRRK2) kinase. It exhibits impressive inhibitory activity with an IC50 (half-maximal inhibitory concentration) of 3 nM. The selective targeting of LRRK2, a protein kinase associated with neurodegenerative disorders like Parkinson’s disease, makes PF-06447475 a promising therapeutic candidate for the treatment of such conditions.