PF-06649298

• CAT Number: I042961
• CAS Number: 1854061-16-7
• Molecular Formula: C16H22O5
• Molecular Weight: 294.34
• Purity: ≥95%
• Synonyms: (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid
• InChI: InChI=1S/C16H22O5/c1-15(2,3)12-6-4-11(5-7-12)8-9-16(21,14(19)20)10-13(17)18/h4-7,21H,8-10H2,1-3H3,(H,17,18)(H,19,20)/t16-/m1/s1
• InChIKey: QNFWRHKLBLSSPB-MRXNPFEDSA-N
• SMILES: CC(C)(C)C1=CC=C(C=C1)CC[C@@](CC(=O)O)(C(=O)O)O

​PF-06649298（Cat No.:I042961）is a potent and selective inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which plays a significant role in cellular energy metabolism by mediating citrate uptake. Inhibition of NaCT has been associated with regulation of glucose and lipid metabolism, making PF-06649298 a valuable tool for metabolic disease research. In preclinical studies, PF-06649298 demonstrated efficacy in reducing plasma glucose levels and hepatic triglycerides in high-fat diet-induced mouse models, suggesting its potential therapeutic application in metabolic disorders.