For research use only. Not for therapeutic Use.
PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM[1].
PF-06795071 shows excellent selectivity against FAAH with an IC50 of 3.1 μM[1].
Catalog Number | I019520 |
CAS Number | 2075629-81-9 |
Synonyms | [(2R)-1,1,1-trifluoro-3-hydroxypropan-2-yl] (1S,5R)-6-[1-(4-fluorophenyl)pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate |
Molecular Formula | C18H17F4N3O3 |
Purity | ≥95% |
InChI | InChI=1S/C18H17F4N3O3/c19-10-1-3-11(4-2-10)25-6-5-14(23-25)16-12-7-24(8-13(12)16)17(27)28-15(9-26)18(20,21)22/h1-6,12-13,15-16,26H,7-9H2/t12-,13+,15-,16?/m1/s1 |
InChIKey | MEDCQBUTCWNKGW-XFDYKOMQSA-N |
SMILES | C1C2C(C2C3=NN(C=C3)C4=CC=C(C=C4)F)CN1C(=O)OC(CO)C(F)(F)F |
Reference | [1]. McAllister LA, et al. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. J Med Chem. 2018 Apr 12;61(7):3008-3026. |