PF-06821497

• CAT Number: I034502
• CAS Number: 1844849-11-1
• Molecular Formula: C22H24Cl2N2O5
• Molecular Weight: 467.34
• Purity: 98%
• Synonyms: PF-06821497; PF06821497; PF 06821497; PF-6821497; PF6821497; PF 6821497.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (S)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one
• InChI: InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m0/s1
• InChIKey: RXCVUHMIWHRLDF-FQEVSTJZSA-N
• SMILES: COC1=C(CN2CCC(C(Cl)=CC([C@@H](OC)C3COC3)=C4Cl)=C4C2=O)C(NC(C)=C1)=O

PF-06821497(CAT: I034502) is a potent and selective inhibitor of EZH2 (enhancer of zeste homolog 2), a key component of the PRC2 (polycomb repressive complex 2) complex, widely used in epigenetics and oncology research. By inhibiting EZH2, it disrupts H3K27 methylation, a critical epigenetic modification involved in gene silencing and cancer progression. This compound is particularly valuable for studying cancers driven by EZH2 dysregulation, such as certain lymphomas and solid tumors. With its high specificity and efficacy, PF-06821497 is an essential tool for preclinical research aimed at developing targeted therapies and understanding the role of epigenetic regulation in malignancies.