For research use only. Not for therapeutic Use.
PF-06843195 Prodrug is a novel prdrug of PF-06843195, a potent PI3Kα-selective inhibitor.
| Catalog Number | I034506 |
| Synonyms | PF-06843195 Prodrug; PF06843195 Prodrug; PF 06843195 Prodrug; |
| Molecular Formula | C20H26F3N8O7P |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2,2-difluoroethyl (S)-3-((2'-amino-5-fluoro-2-morpholino-[4,5'-bipyrimidin]-6-yl)amino)-3-((phosphonooxy)methyl)pyrrolidine-1-carboxylate |
| InChI | InChI=1S/C20H26F3N8O7P/c21-13(22)9-37-19(32)31-2-1-20(10-31,11-38-39(33,34)35)29-16-14(23)15(12-7-25-17(24)26-8-12)27-18(28-16)30-3-5-36-6-4-30/h7-8,13H,1-6,9-11H2,(H2,24,25,26)(H,27,28,29)(H2,33,34,35)/t20-/m0/s1 |
| InChIKey | UCGFIRPRWMWKQG-FQEVSTJZSA-N |
| SMILES | NC(N=C1)=NC=C1C2=NC(N3CCOCC3)=NC(N[C@]4(COP(O)(O)=O)CN(C(OCC(F)F)=O)CC4)=C2F |
| Reference | 1: Cheng H, Orr STM, Bailey S, Brooun A, Chen P, Deal JG, Deng YL, Edwards MP, Gallego GM, Grodsky N, Huang B, Jalaie M, Kaiser S, Kania RS, Kephart SE, Lafontaine J, Ornelas MA, Pairish M, Planken S, Shen H, Sutton S, Zehnder L, Almaden CD, Bagrodia S, Falk MD, Gukasyan HJ, Ho C, Kang X, Kosa RE, Liu L, Spilker ME, Timofeevski S, Visswanathan R, Wang Z, Meng F, Ren S, Shao L, Xu F, Kath JC. Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195). J Med Chem. 2021 Jan 14;64(1):644-661. doi: 10.1021/acs.jmedchem.0c01652. Epub 2020 Dec 24. PMID: 33356246. |
