PF-06869206

• CAT Number: I020092
• CAS Number: 2227425-05-8
• Molecular Formula: C₁₅H₁₄ClF₃N₄O₂
• Molecular Weight: 374.74
• Purity: ≥95%
• Target: Sodium Channel
• Storage: 2-8°C
• IUPAC Name: 3-chloro-7-[(2S)-2-(hydroxymethyl)morpholin-4-yl]-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
• InChI: InChI=1S/C15H14ClF3N4O2/c1-7-10(16)11-12(21-7)13(23-2-3-25-8(5-23)6-24)9(4-20)14(22-11)15(17,18)19/h8,21,24H,2-3,5-6H2,1H3/t8-/m0/s1
• InChIKey: ATFQBBCQZKVZJN-QMMMGPOBSA-N
• SMILES: CC1=C(C2=C(N1)C(=C(C(=N2)C(F)(F)F)C#N)N3CCOC(C3)CO)Cl

PF-06869206 (Cat No.:I020092) is a potent, orally active and selective sodium phosphate cotransporter NaPi2a (SLC34A1) inhibitor with IC50 of 380 nM. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Filipski KJ, et al. Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett. 2018 Apr 12;9(5):440-445.