PF-06873600

• CAT Number: I019663
• CAS Number: 2185857-97-8
• Molecular Formula: C₂₀H₂₇F₂N₅O₄S
• Molecular Weight: 471.52
• Purity: ≥95%
• Target: CDK
• Storage: Store at -20°C
• IUPAC Name: 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrido[2,3-d]pyrimidin-7-one
• InChI: InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25)/t15-,20-/m1/s1
• InChIKey: QIEKHLDZKRQLLN-FOIQADDNSA-N
• SMILES: CC1(CCCC1N2C3=NC(=NC=C3C=C(C2=O)C(F)F)NC4CCN(CC4)S(=O)(=O)C)O

PF-06873600（Cat No.:I019663） is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. PF-06873600 has potential antineoplastic activity. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. US 2018/0044344 A1.[2]. NCI Drug Dictionary