For research use only. Not for therapeutic Use.
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd)[1].
PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression[1].
| Catalog Number | I019333 |
| CAS Number | 2378173-15-8 |
| Synonyms | (1R,2S)-2-[(7-oxo-5-phenyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid |
| Molecular Formula | C20H20N4O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20N4O4/c25-17-10-16(12-6-2-1-3-7-12)22-18-14(11-21-24(17)18)19(26)23-15-9-5-4-8-13(15)20(27)28/h1-3,6-7,10-11,13,15,21H,4-5,8-9H2,(H,23,26)(H,27,28)/t13-,15+/m1/s1 |
| InChIKey | WGQGCLHXUPGUSZ-HIFRSBDPSA-N |
| SMILES | C1CCC(C(C1)C(=O)O)NC(=O)C2=CNN3C2=NC(=CC3=O)C4=CC=CC=C4 |
| Reference | [1]. Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843. |
