For research use only. Not for therapeutic Use.
PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents.
| Catalog Number | I045454 |
| CAS Number | 2159123-14-3 |
| Synonyms | (1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy]-5-(4-methylpyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol |
| Molecular Formula | C22H23F3N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H23F3N4O3/c1-10-11-3-5-29(22(11)28-9-27-10)15-7-17(20(31)19(15)30)32-16-6-13(21(24)25)18(23)12-2-4-26-8-14(12)16/h3,5-6,9,15,17,19-21,26,30-31H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1 |
| InChIKey | HBGHQRGHFNTSDP-DJABAAGCSA-N |
| SMILES | CC1=C2C=CN(C2=NC=N1)C3CC(C(C3O)O)OC4=C5CNCCC5=C(C(=C4)C(F)F)F |
| Reference | [1]. Adli M. Combinatorial drug treatment of cancer. WO2020198601A1. |
