PF-06952229

• CAT Number: I015468
• CAS Number: 1801333-55-0
• Molecular Formula: C₂₃H₂₄ClFN₄O₃
• Molecular Weight: 458.91
• Purity: ≥95%
• Target: TGF-β Receptor

PF-06952229 (Cat.No:I015468) is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer.

Reference

[1]. Flavia Mercer Pernasetti, et al. Combinations of tgfb inhibitors and cdk inhibitors for the treatment of breast cancer. Patent WO2020058820A1.