PF-07258669

• CAT Number: I042623
• CAS Number: 2755890-53-8
• Molecular Formula: C25H27FN6O2
• Molecular Weight: 462.52
• Purity: ≥95%
• Synonyms: (2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-pyrimidin-2-ylspiro[3,4-dihydro-1H-1,8-naphthyridine-2,3′-pyrrolidine]-1′-yl]propan-1-one
• InChI: InChI=1S/C25H27FN6O2/c1-15(18-12-21(34-3)29-13-20(18)26)24(33)32-10-7-25(14-32)6-5-17-11-19(16(2)30-22(17)31-25)23-27-8-4-9-28-23/h4,8-9,11-13,15H,5-7,10,14H2,1-3H3,(H,30,31)/t15-,25+/m1/s1
• InChIKey: PARGFYLSRQUWHR-BZQUYTCOSA-N
• SMILES: CC1=C(C=C2CCC3(CCN(C3)C(=O)C(C)C4=CC(=NC=C4F)OC)NC2=N1)C5=NC=CC=N5

PF-07258669 is a melanocortin-4 receptor (MC4) antagonist. PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa[1].

Reference

[1]. Christopher Ryan BUTLER, et al. Spiro compounds as melanocortin 4 receptor antagonists and uses thereof. Patent. WO2021250541A1.