PF-07284892

• CAT Number: I041217
• CAS Number: 2498597-94-5
• Molecular Formula: C21H22ClN7S
• Molecular Weight: 439.96
• Purity: ≥95%
• Synonyms: (1S)-1′-[6-(3-amino-2-chlorophenyl)sulfanyl-1,2,4-triazin-3-yl]spiro[1,3-dihydroindene-2,4′-piperidine]-1-amine
• IUPAC Name: (1S)-1'-[6-(2-amino-3-chloropyridin-4-yl)sulfanyl-1,2,4-triazin-3-yl]spiro[1,3-dihydroindene-2,4'-piperidine]-1-amine
• InChI: InChI=1S/C21H22ClN7S/c22-17-15(5-8-25-19(17)24)30-16-12-26-20(28-27-16)29-9-6-21(7-10-29)11-13-3-1-2-4-14(13)18(21)23/h1-5,8,12,18H,6-7,9-11,23H2,(H2,24,25)/t18-/m1/s1
• InChIKey: HZCJDRDHKWNUGN-GOSISDBHSA-N
• SMILES: C1CN(CCC12CC3=CC=CC=C3[C@H]2N)C4=NC=C(N=N4)SC5=C(C(=NC=C5)N)Cl

PF-07284892（Cat No.:I041217）is a selective inhibitor of the protein kinase RIPK1 (receptor-interacting protein kinase 1), a key regulator in inflammatory and cell death pathways. By inhibiting RIPK1, PF-07284892 has the potential to modulate necroptosis and inflammation, which are involved in various diseases, including autoimmune disorders, neurodegenerative diseases, and inflammatory conditions. The compound is being investigated in clinical trials for its therapeutic potential in conditions like rheumatoid arthritis, inflammatory bowel disease, and Alzheimer’s disease. Ongoing research is focused on evaluating its safety, efficacy, and long-term benefits in treating these diseases.