PF-07284892

For research use only. Not for therapeutic Use.

  • CAT Number: I041217
  • CAS Number: 2498597-94-5
  • Molecular Formula: C21H22ClN7S
  • Molecular Weight: 439.96
  • Purity: ≥95%
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PF-07284892(Cat No.:I041217)is a selective inhibitor of the protein kinase RIPK1 (receptor-interacting protein kinase 1), a key regulator in inflammatory and cell death pathways. By inhibiting RIPK1, PF-07284892 has the potential to modulate necroptosis and inflammation, which are involved in various diseases, including autoimmune disorders, neurodegenerative diseases, and inflammatory conditions. The compound is being investigated in clinical trials for its therapeutic potential in conditions like rheumatoid arthritis, inflammatory bowel disease, and Alzheimer’s disease. Ongoing research is focused on evaluating its safety, efficacy, and long-term benefits in treating these diseases.


CAS Number 2498597-94-5
Synonyms

(1S)-1′-[6-(3-amino-2-chlorophenyl)sulfanyl-1,2,4-triazin-3-yl]spiro[1,3-dihydroindene-2,4′-piperidine]-1-amine

Molecular Formula C21H22ClN7S
Purity ≥95%
IUPAC Name (1S)-1'-[6-(2-amino-3-chloropyridin-4-yl)sulfanyl-1,2,4-triazin-3-yl]spiro[1,3-dihydroindene-2,4'-piperidine]-1-amine
InChI InChI=1S/C21H22ClN7S/c22-17-15(5-8-25-19(17)24)30-16-12-26-20(28-27-16)29-9-6-21(7-10-29)11-13-3-1-2-4-14(13)18(21)23/h1-5,8,12,18H,6-7,9-11,23H2,(H2,24,25)/t18-/m1/s1
InChIKey HZCJDRDHKWNUGN-GOSISDBHSA-N
SMILES C1CN(CCC12CC3=CC=CC=C3[C@H]2N)C4=NC=C(N=N4)SC5=C(C(=NC=C5)N)Cl

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