PF 1022A

• CAT Number: I001274
• CAS Number: 133413-70-4
• Molecular Formula: C52H76N4O12
• Molecular Weight: 949.18
• Purity: ≥95%
• Solubility: DMSO: ≥ 43 mg/mL
• Storage: Desiccate at -20°C
• IUPAC Name: (3S,6R,9S,12R,15S,18R,21S,24R)-6,18-dibenzyl-4,10,12,16,22,24-hexamethyl-3,9,15,21-tetrakis(2-methylpropyl)-1,7,13,19-tetraoxa-4,10,16,22-tetrazacyclotetracosane-2,5,8,11,14,17,20,23-octone
• InChI: InChI=1S/C52H76N4O12/c1-31(2)25-39-49(61)65-35(9)45(57)53(11)42(28-34(7)8)52(64)68-44(30-38-23-19-16-20-24-38)48(60)56(14)40(26-32(3)4)50(62)66-36(10)46(58)54(12)41(27-33(5)6)51(63)67-43(47(59)55(39)13)29-37-21-17-15-18-22-37/h15-24,31-36,39-44H,25-30H2,1-14H3/t35-,36-,39+,40+,41+,42+,43-,44-/m1/s1
• InChIKey: YJNUXGPXJFAUQJ-LYWANRAQSA-N
• SMILES: CC1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC(C)C)C)CC2=CC=CC=C2)CC(C)C)C)C)CC(C)C)C)CC3=CC=CC=C3)CC(C)C)C

PF1022A (Cat No.:I001274) is a peptide with broad-spectrum anthelmintic properties produced by fermenting mycelium mycelia. PF1022A is a channel-forming ionophore. PF1022A has potent anthelmintic activity against Ascaridiagalli in chickens. PF1022 can also be used in the study of vascular smooth muscle disease.

Reference

[1]. Sasaki T, et al. A new anthelmintic cyclodepsipeptide, PF1022A. J Antibiot (Tokyo). 1992 May;45(5):692-7.
[2]. Dornetshuber R, et al. Effects of the anthelmintic drug PF1022A on mammalian tissue and cells. Biochem Pharmacol. 2009 Apr 15;77(8):1437-44.
[3]. Nwosu U, et al. Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo. Parasitology. 2011 Aug;138(9):1193-201.