For research use only, not for therapeutic use.
PF-3758309（Cat No.:I005375）is a potent small-molecule inhibitor of PAK4 (p21-activated kinase 4), a serine/threonine kinase involved in regulating cell motility, survival, and proliferation. By inhibiting PAK4, PF-3758309 disrupts critical signaling pathways, including the MAPK and PI3K/Akt pathways, which are often dysregulated in cancer. This compound has shown promise in preclinical studies for its ability to halt tumor growth and induce apoptosis in cancer cells. PF-3758309 is widely used in cancer research to explore the therapeutic potential of targeting PAK4 in various cancers, including pancreatic and breast cancer.
| Catalog Number | I005375 |
| CAS Number | 898044-15-0 |
| Synonyms | N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide |
| Molecular Formula | C25H30N8OS |
| Purity | ≥95% |
| Target | PAK4 |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 1.3 nM (PAK4) |
| IUPAC Name | N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide |
| InChI | InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1 |
| InChIKey | AYCPARAPKDAOEN-LJQANCHMSA-N |
| SMILES | CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)N[C@H](CN(C)C)C5=CC=CC=C5)SC=C2 |
| Reference | <p style=/line-height:25px/> |
