PF-4136309

• CAT Number: I047415
• CAS Number: 857679-55-1
• Molecular Formula: C29H31F3N6O3
• Molecular Weight: 568.59
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: OC1(CCC(CC1)NC2CCN(C2)C(=O)CNC(=O)C3=CC(=CC=C3)C(F)(F)F)C4=NC=C(C=C4)C5=NC=CC=N5

PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2.

Reference

[1] Xianming Deng, et, al. Eur J Med Chem. 2013;70:758-67.
[2] Xue CB, et al. ACS Med Chem Lett. 2011 Oct 5;2(12):913-8.