PF-431396

• CAT Number: I004677
• CAS Number: 717906-29-1
• Molecular Formula: C₂₂H₂₁F₃N₆O₃S
• Molecular Weight: 506.51
• Purity: ≥95%
• Synonyms: N-methyl-N-[2-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
• Target: Pyk2
• Solubility: DMSO: ≥ 100 mg/mL, H2O: <1 mg/mL
• Storage: Store at -20C
• IC50: 2 nM (FAK); 11 nM (PYK2); 445 nM (KD for BRD4) [1] [2]
• InChI: InChI=1S/C22H21F3N6O3S/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30)
• InChIKey: POJZIZBONPAWIV-UHFFFAOYSA-N
• SMILES: CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C

PF-431396(CAT: I004677) is a potent and selective dual inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2). Widely utilized in cancer and cell signaling research, it targets key pathways involved in cell adhesion, migration, and survival. By disrupting FAK and Pyk2 activity, PF-431396 inhibits tumor progression, metastasis, and angiogenesis, making it a valuable tool for studying cancer biology. Additionally, it aids in exploring therapeutic strategies for fibrotic diseases and inflammatory conditions. Its high specificity and effectiveness in modulating tyrosine kinase pathways provide researchers with a reliable compound for advancing drug discovery and mechanistic studies.