PF-477736

• CAT Number: I005651
• CAS Number: 952021-60-2
• Molecular Formula: C22H25N7O2
• Molecular Weight: 419.48
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(C5CCCCC5)N)N2

PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.

Reference

[1] Blasina A, et al. Mol Cancer Ther, 2008, 7(8), 2394-2404.
[2] Chakraborty J, et al. J Biol Chem, 2010, 285(43), 33104-33112.
[3] Zhang C, et al. Clin Cancer Res, 2009, 15(14), 4630-4640.
[4] Carrassa L, et al. Cell Cycle, 2012, 11(13), 2507-2517.