PF-4800567

For research use only, not for therapeutic use.

  • CAT Number: I008710
  • CAS Number: 1188296-52-7
  • Molecular Formula: C17H18ClN5O2
  • Molecular Weight: 359.81
  • Purity: ≥95%
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PF-4800567 (Cat No.:I008710) is a selective inhibitor of casein kinase 1ε (CK1ε). It exhibits a high level of selectivity for CK1ε, with an IC50 (half maximal inhibitory concentration) value of 32 nM. It demonstrates more than 20-fold selectivity over CK1δ, another isoform of casein kinase 1. Casein kinases are involved in regulating various cellular processes, including cell division, circadian rhythm, and signal transduction pathways. By specifically inhibiting CK1ε, PF-4800567 has the potential to modulate CK1ε-mediated signaling pathways and provide insights into its functional role in cellular physiology and disease processes.


Catalog Number I008710
CAS Number 1188296-52-7
Synonyms

PF-4800567; PF 4800567; PF4800567.;3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine

Molecular Formula C17H18ClN5O2
Purity ≥95%
Target Casein Kinase Inhibitor
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine
InChI InChI=1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21)
InChIKey AUMDBEHGJRZSOO-UHFFFAOYSA-N
SMILES C1COCCC1N2C3=NC=NC(=C3C(=N2)COC4=CC(=CC=C4)Cl)N
Reference

</br>1. Walton, K.M.,Fisher, K.,Rubitski, D., et al. Selective inhibition of casein kinase 1ε minimally alters circadian clock period. Journal of Pharmacology and Experimental Therapeutics 330(2), 430-439 (2009).

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