PF-543 Citrate

• CAT Number: I001589
• CAS Number: 1415562-83-2
• Molecular Formula: C33H39NO11S
• Molecular Weight: 657.73
• Purity: ≥95%
• Synonyms: [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol;2-hydroxypropane-1,2,3-tricarboxylic acid
• Target: GPCR/G Protein
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 3.6 nM (Ki)
• InChI: 1S/C27H31NO4S.C6H8O7/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29;7-3(8)1-6(13,5(11)12)2-4(9)10/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t25-;/m1./s1
• InChIKey: PWXXWUWKNPXSGW-VQIWEWKSSA-N
• SMILES: CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCC[C@@H]3CO)CS(=O)(=O)C4=CC=CC=C4.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

PF-543 Citrate (Cat.No:I001589) is a selective inhibitor of Sphingosine Kinase 1 (SphK1), an enzyme involved in the regulation of sphingolipid metabolism. By targeting SphK1, PF-543 Citrate modulates cellular signaling pathways related to cell proliferation, apoptosis, and inflammation. It holds potential as a therapeutic agent in various diseases, including cancer and inflammatory disorders.