PF-543 Citrate

• CAT Number: I001589
• CAS Number: 1415562-83-2
• Molecular Formula: C33H39NO11S
• Molecular Weight: 657.73
• Purity: ≥95%
• Synonyms: [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol;2-hydroxypropane-1,2,3-tricarboxylic acid
• Target: SPHK
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 3.6 nM (Ki)

PF-543 Citrate (Cat.No:I001589) is a selective inhibitor of Sphingosine Kinase 1 (SphK1), an enzyme involved in the regulation of sphingolipid metabolism. By targeting SphK1, PF-543 Citrate modulates cellular signaling pathways related to cell proliferation, apoptosis, and inflammation. It holds potential as a therapeutic agent in various diseases, including cancer and inflammatory disorders.

Reference

[1]. Schnute ME, McReynolds MD, Kasten T et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.
[2]. Lynch KR. Building a better sphingosine kinase-1 inhibitor. Biochem J. 2012 May 15;444(1):e1-2.