PF-543

• CAT Number: I001588
• CAS Number: 1415562-82-1
• Molecular Formula: C27H31NO4S
• Molecular Weight: 465.60
• Purity: ≥95%
• Synonyms: [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol
• Target: GPCR/G Protein
• Solubility: 10 mM in DMSO
• Storage: 3 years -20 ℃
• IC50: 3.6 nM (Ki)
• InChI: InChI=1S/C27H31NO4S/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3/t25-/m1/s1
• InChIKey: NPUXORBZRBIOMQ-RUZDIDTESA-N
• SMILES: CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCC[C@@H]3CO)CS(=O)(=O)C4=CC=CC=C4

PF-543（Cat No.:I001588）is a selective inhibitor of the enzyme autotaxin (ATX), which plays a key role in the production of lysophosphatidic acid (LPA), a lipid signaling molecule involved in various cellular processes, including inflammation, fibrosis, and cancer metastasis. By inhibiting autotaxin, PF-543 reduces LPA levels, which may help in treating conditions related to excessive LPA signaling, such as cancer, fibrotic diseases, and cardiovascular disorders. Preclinical studies suggest that PF-543 could have therapeutic potential in modulating fibrosis and tumor progression. Further research is needed to assess its clinical safety and efficacy.