PF-562271 besylate

• CAT Number: I005582
• CAS Number: 939791-38-5
• Molecular Formula: C₂₁H₂₀F₃N₇O₃S • CH₆O₃S
• Molecular Weight: 665.66
• Purity: ≥95%
• Synonyms: PF562271 besylate
• Target: FAK
• Solubility: DMSO: ≤ 24.5 mg/mL
• Storage: 3 years -20C powder
• IC50: 1.5 nM(FAK); 14 nM(Pyk2)
• IUPAC Name: benzenesulfonic acid;N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide
• InChI: InChI=1S/C21H20F3N7O3S.C6H6O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16;7-10(8,9)6-4-2-1-3-5-6/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30);1-5H,(H,7,8,9)
• InChIKey: LKLWTLXTOVZFAE-UHFFFAOYSA-N
• SMILES: CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.C1=CC=C(C=C1)S(=O)(=O)O

PF-562271 Besylate(CAT: I005582) is a potent and selective inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), two key regulators of cell adhesion, migration, and survival. By targeting these kinases, it disrupts tumor progression and metastasis, making it particularly valuable in oncology research. PF-562271 Besylate is widely used to study the role of FAK/Pyk2 in cancer cell signaling, angiogenesis, and the tumor microenvironment. Its high specificity and efficacy make PF-562271 Besylate a critical tool for exploring novel therapeutic strategies and advancing cancer research, particularly in drug discovery and development.