For research use only. Not for therapeutic Use.
PF-6422899 (Cat.No:I011991) is an irreversible inhibitor of EGFR kinase activity. PF-6422899 binds covalently to active-site cysteine residues in the ATP binding pocket of EGFR.
| Catalog Number | I011991 |
| CAS Number | 1621002-23-0 |
| Synonyms | PF-6422899; PF6422899; PF 6422899;;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(2-propyn-1-yloxy)-6-quinazolinyl]-2-propenamide |
| Molecular Formula | C20H14ClFN4O2 |
| Purity | ≥95% |
| Target | EGFR kinase inhibitor |
| Solubility | Soluble in DMSO |
| Storage | Store at 0-8 °C |
| InChI | InChI=1S/C20H14ClFN4O2/c1-3-7-28-18-10-16-13(9-17(18)26-19(27)4-2)20(24-11-23-16)25-12-5-6-15(22)14(21)8-12/h1,4-6,8-11H,2,7H2,(H,26,27)(H,23,24,25) |
| InChIKey | AZLXGJFHSLQCPV-UHFFFAOYSA-N |
| SMILES | C=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC#C)=O |
