For research use only, not for therapeutic use.
PF-670462 (Cat No.:I005648) is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations. PF-670462, a selective CK1 ε/δ inhibitor, causes a significant phase delay in animal models of circadian rhythm; it remains unclear whether one of the kinases has a predominant role in regulating the circadian clock. In transfected whole cell assays, it caused a concentration-related redistribution of nuclear versus cytosolic PER. When tested in free-running animals, 50 mg/kg s.c. PF-670462 produced robust phase delays when dosed at circadian time (CT)9 (-1.97 ± 0.17 h). PF-670462 attenuates methamphetamine-stimulated locomotion in vivo.
Catalog Number | I005648 |
CAS Number | 950912-80-8 |
Synonyms | PF670462;PF 670462 |
Molecular Formula | C19H20FN5 • 2HCl |
Purity | ≥95% |
Target | CK1 |
Solubility | DMSO: ≥ 32 mg/mL |
Storage | Store at -20°C |
IC50 | 7.7 nM |
IUPAC Name | 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine;dihydrochloride |
InChI | InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H |
InChIKey | PSNKGVAXBSAHCH-UHFFFAOYSA-N |
SMILES | C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl |
Reference | <p> |