For research use only. Not for therapeutic Use.
JAK3 inhibitor and close analogue of CP 690550 (Tofacitinib; Axon 1338 and Axon 2072). Useful tool compound to study JAK3 inhibition in the treatment of various diseases, particularly asthma and COPD, and rheumatoid arthritis.
| CAS Number | 1262832-74-5 |
| Molecular Formula | C18H26N6O |
| Purity | ≥95% |
| IUPAC Name | [(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-pyrrolidin-1-ylmethanone |
| InChI | InChI=1S/C18H26N6O/c1-13-6-10-24(18(25)23-8-3-4-9-23)11-15(13)22(2)17-14-5-7-19-16(14)20-12-21-17/h5,7,12-13,15H,3-4,6,8-11H2,1-2H3,(H,19,20,21)/t13-,15+/m1/s1 |
| SMILES | C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)N4CCCC4 |
| Reference | A.J. Steele et al. The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of (…). Blood 2010, 116(22), 4569-4577.
P.S. Changelian et al. The specificity of JAK3 kinase inhibitors. Blood, 2008, 111(4), 2155-2157. |
