For research use only. Not for therapeutic Use.
PF15 TFA(CAT: I041011) is a selective inhibitor of the protein-protein interaction between p53 and its negative regulator MDM2, which is crucial for maintaining cellular homeostasis and tumor suppression. By disrupting the p53-MDM2 interaction, PF15 TFA stabilizes the p53 tumor suppressor, promoting cell cycle arrest, apoptosis, and DNA damage repair in cancer cells. This compound has shown strong potential in preclinical models of various cancers, including leukemia and solid tumors. PF15 TFA offers a novel strategy to reactivate p53-mediated tumor suppression, making it a promising candidate for cancer therapies targeting p53 dysfunction, a common hallmark in many cancers.
| Synonyms | 5-[4-[4-[4-amino-5-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]butyl]triazol-1-yl]-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pentanamide;2,2,2-trifluoroacetic acid |
| Molecular Formula | C46H50F3N13O8 |
| Purity | ≥95% |
| IUPAC Name | 5-[4-[4-[4-amino-5-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]butyl]triazol-1-yl]-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pentanamide;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C44H49N13O6.C2HF3O2/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-6-4-9-28-22-56(54-52-28)20-7-5-12-36(58)49-32-11-8-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60;3-2(4,5)1(6)7/h8,10-11,13-16,21-23,25,33H,4-7,9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62);(H,6,7) |
| InChIKey | UBUIPNHJWCIQPV-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN(C4=NC=NC(=C34)N)CCCCC5=CN(N=N5)CCCCC(=O)NC6=CC=CC7=C6CN(C7=O)C8CCC(=O)NC8=O.C(=O)(C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
