For research use only. Not for therapeutic Use.
PfDHODH-IN-1（Cat No.:I016867）is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), an enzyme crucial for the parasite’s pyrimidine biosynthesis. By targeting PfDHODH, PfDHODH-IN-1 disrupts DNA and RNA synthesis in the malaria-causing parasite, exhibiting antimalarial activity. As an analog of leflunomide’s active metabolite, it offers a promising avenue for developing new antimalarial therapies, especially against drug-resistant strains. Its specificity for PfDHODH over human DHODH reduces potential host toxicity, making it a valuable candidate in malaria research and drug development.
| Catalog Number | I016867 |
| CAS Number | 183945-55-3 |
| Molecular Formula | C₁₄H₁₁F₃N₂O₂ |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | 4°C, protect from light |
| IUPAC Name | (Z)-2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]prop-2-enamide |
| InChI | InChI=1S/C14H11F3N2O2/c15-14(16,17)9-3-5-10(6-4-9)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,20H,1-2H2,(H,19,21)/b12-11- |
| InChIKey | IKNOIAXAHSRIGK-QXMHVHEDSA-N |
| SMILES | C1CC1/C(=C(\C#N)/C(=O)NC2=CC=C(C=C2)C(F)(F)F)/O |
| Reference | [1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.<br>[2]. Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24. |
