For research use only. Not for therapeutic Use.
PfDHODH-IN-1（Cat No.:I016867） is an analog of the active metabolite of leflunomide, and it acts as an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). PfDHODH is an enzyme involved in the synthesis of pyrimidine nucleotides essential for the growth and survival of the malaria parasite. By inhibiting PfDHODH, PfDHODH-IN-1 demonstrates antimalarial activity.
| Catalog Number | I016867 |
| CAS Number | 183945-55-3 |
| Molecular Formula | C₁₄H₁₁F₃N₂O₂ |
| Purity | ≥95% |
| Storage | 4°C, protect from light |
| IUPAC Name | (Z)-2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]prop-2-enamide |
| InChI | InChI=1S/C14H11F3N2O2/c15-14(16,17)9-3-5-10(6-4-9)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,20H,1-2H2,(H,19,21)/b12-11- |
| InChIKey | IKNOIAXAHSRIGK-QXMHVHEDSA-N |
| SMILES | C1CC1C(=C(C#N)C(=O)NC2=CC=C(C=C2)C(F)(F)F)O |
| Reference | [1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.<br>[2]. Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24. |
