PFI-2 hydrochloride

• CAT Number: I002099
• CAS Number: 1627607-87-7
• Molecular Formula: C23H25F4N3O3S • HCl
• Molecular Weight: 536
• Purity: ≥95%
• Synonyms: (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride
• Target: Histone Methyltransferase
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: 2-8°C
• IC50: 2 nM
• IUPAC Name: 8-fluoro-N-[(2R)-1-oxo-1-pyrrolidin-1-yl-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide;hydrochloride
• InChI: InChI=1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m1./s1
• InChIKey: ZADKZNVAJGEFLC-ZMBIFBSDSA-N
• SMILES: C1CCN(C1)C(=O)C(CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=C(CNCC4)C(=C3)F.Cl

PFI-2 hydrochloride（Cat No.:I002099）, is a chemical compound with significance in the field of epigenetics and molecular biology. It functions as a potent and selective inhibitor targeting a specific class of enzymes known as SETD7, which are responsible for adding methyl groups to histone proteins. By inhibiting SETD7, PFI-2 hydrochloride has the potential to modulate epigenetic regulation, impacting gene expression and cellular processes.

Reference

[1]. Barsyte-Lovejoy D, et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8.