PFK-015

• CAT Number: I003553
• CAS Number: 4382-63-2
• Molecular Formula: C17H12N2O
• Molecular Weight: 260.3
• Purity: ≥95%
• Synonyms: 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
• Target: Autophagy
• Solubility: DMSO: ≤ 25.2 mg/mL
• Storage: 2-8°C
• IC50: 110 nM (recombinant PFKFB3)[1]
• IUPAC Name: (E)-1-pyridin-4-yl-3-quinolin-2-ylprop-2-en-1-one
• InChI: InChI=1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
• InChIKey: UJJUKZPBUMCSJZ-BQYQJAHWSA-N
• SMILES: C1=CC=C2C(=C1)C=CC(=N2)C=CC(=O)C3=CC=NC=C3

PFK-015 (Cat No.: I003553) is a highly potent and selective inhibitor of 6-phosphofructo-2-kinase (PFKFB3) with an impressive IC50 of 207 nM. This compound has demonstrated the ability to induce significant growth inhibition in a wide spectrum of cancer cells. The inhibition of PFKFB3 is of particular interest in cancer research, as it impacts glycolysis and cellular energy metabolism, processes crucial for the rapid growth of cancer cells. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Brian Clem, et al. Abstract 2825: Characterization of a novel small molecule antagonist of 6-phosphofructo-2-kinase that suppresses glucose metabolism and tumor growth. Cancer Research: April 15, 2011; Volume 71, Issue 8, Supplement 1