PFK-158

• CAT Number: I001771
• CAS Number: 1462249-75-7
• Molecular Formula: C18H11F3N2O
• Molecular Weight: 328.29
• Purity: ≥95%
• Target: Apoptosis
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: -20°C

PFK-158 (Cat.No:I001771) is a small molecule inhibitor that targets phosphofructokinase-1 (PFK-1), a key enzyme involved in glycolysis. By inhibiting PFK-1, PFK-158 disrupts the metabolic pathways of cancer cells, leading to energy depletion and impaired tumor growth. It shows promise as a potential anticancer therapy and is currently being investigated in preclinical studies.

Reference

[1]. Rebecca Redman, et al. Abstract CT206: PFK-158, first-in-man and first-in-class inhibitor of PFKFB3/ glycolysis: A phase I, dose escalation, multi-center study in patients with advanced solid malignancies. Cancer Res August 1, 2015 75; CT206. doi: 10.1158/1538-7445.AM2015-CT206.

[2]. Sucheta Telang, et al. Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib. Cancer Metab. 2014; 2(Suppl 1): P14.