For research use only. Not for therapeutic Use.
PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ)[1].
PFM03 (50-400 μM; 30 min) specifically inhibits MRE11 endonuclease activity[1].
PFM03 (100 μM; 30 min) causes normal DSB repair in G2 (CENPF+) cells[1].
PFM03 (50 μM; 8 h) enhances NHEJ usage but reduces homologous recombination (HR) in cells[1].
| Catalog Number | I042895 |
| CAS Number | 1558598-48-3 |
| Synonyms | (5Z)-3-butan-2-yl-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one |
| Molecular Formula | C14H15NO2S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H15NO2S2/c1-3-9(2)15-13(17)12(19-14(15)18)8-10-4-6-11(16)7-5-10/h4-9,16H,3H2,1-2H3/b12-8- |
| InChIKey | REONZIRLQDMCHL-WQLSENKSSA-N |
| SMILES | CCC(C)N1C(=O)C(=CC2=CC=C(C=C2)O)SC1=S |
| Reference | [1]. Shibata A, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18. |
